Pedro has alternated with Willian for much of this season, though both stars could be rested for Thursday's clash.
Victor Moses' wing-back role was made redundant following the switch away from Antonio Conte's 3-4-3 system, but has showed glimpses of quality in his former position on the wing.
He could start on the right flank with teenager Callum Hudson-Odoi pushing for his first taste of senior squad action since the Community Shield clash with Manchester City.
This could be a perfect opportunity to deploy the young English prospect given Pedro's current injury status.
Chelsea team news: How will the Blues line up vs Vidi? (Image: Getty Images/buildlineup.com)
Chelsea team news: Express Sport's predicted XI vs Vidi (Image: buildlineup.com)
Chelsea team news: Alvaro Morata will be desperate for a goal (Image: Getty Images)
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The usual midfield trio of Mateo Kovacic, Jorginho and N'Golo Kante is likely to be swapped out for Cesc Fabregas, Ross Barkley and Loftus-Cheek.
Elsewhere, Alvaro Morata will lead the line and will be desperate to rebuild his confidence after a near-barren start to the 2018/19 campaign.