His Bernabeu exit comes less than five months after he was sacked as the manager of the Spain national team days before the World Cup having failed to tell them of his plans to take over at Real Madrid.
But Calderon - who was president of the club between 2006 and 2009 - thinks that current chief Perez must take the blame for Madrid’s struggles.
That’s after all-time top goalscorer Ronaldo was allowed to end a nine-year stay with Real in July to join Juventus in an £88.8million deal.
Despite links to possible replacements such as Eden Hazard, Neymar and Kylian Mbappe, Los Bancos opted not to recruit a high-profile successor to their star man - only bringing Mariano Diaz back from Lyon for around £30m.
Calderon has blamed Lopetegui's exit on Perez for allowing Cristiano Ronaldo to leave (Image: GETTY)
Ramon Calderon was the Real Madrid president for three years (Image: GETTY)
Julen Lopetegui was sacked on Monday night (Image: GETTY)
Invalid email
We use your sign-up to provide content in ways you've consented to and to improve our understanding of you. This may include adverts from us and 3rd parties based on our understanding. You can unsubscribe at any time. Read our Privacy Policy
And Calderon sees that as a critical error on the club’s part - insisting Lopetegui is not the one to blame for Real’s worst start to a season in almost a decade.
"Unfortunately it's another of the president's whims," Calderon said.
"If he was the right man in June, only four months ago, he cannot be unfit now.
"He signed him just two days before the World Cup started, so damaging our national team and now he's sacking him.
“I that's the problem, I think he [Lopetegui] is not the one to be blamed.
"That has been the main trouble, to transfer Cristiano in June has been a historic mistake and we are paying for that now."
Real Madrid Castilla boss Santiago Solari will take temporary charge of the club’s first team with Antonio Conte tipped to take over.
Due to Spanish Football Federation stipulations, Madrid must appoint a new permanent boss within two weeks - offering Solari a potential four-game stint to prove himself.
Florentino Perez is the current Los Blancos chief (Image: GETTY)
Julen Lopetegui's tenure lasted just 14 matches (Image: GETTY)
Cristiano Ronaldo left Real Madrid for Juventus in the summer (Image: GETTY)
Ronaldo, meanwhile, has declared that he ended his hugely-successful Madrid spell because he did not feel completely valued by Perez and then club.
He revealed toFrance Football: “He [Perez] only ever looked at me as a business relationship. I know it. What he told me never came from the heart.
"I felt it inside the club, especially from the president, that they no longer considered me the same way that they did in the start. In the first four or five years there, I had the feeling of being 'Cristiano Ronaldo'. Less afterwards.
“The president looked at me through eyes that didn't want to say the same thing, as if I was no longer indispensable to them, if you know what I mean. That's what made me think about leaving.
"Sometimes I'd look at the news, where they were saying I was asking to leave. There was a bit of that, but the truth is that I always had the impression that the president would not hold me back.
"If it had all been about money, I'd have moved to China, where I would have earned five times as much than here [at Juventus] or at Real. I did not come to Juve for the money. I earned the same in Madrid, if not more.
"The difference is that, at Juve, they really wanted me. They told me that and made it clear. They showed me that."