Yellow cards are wiped after the quarter-final stage of the Champions League, but only for players who did not already have two to their name.
Winks has been ruled out for the remainder of the season after undergoing groin surgery.
As a result of Pochettino’s selection problems it is predicted he could adopt a 3-4-3 formation.
Toby Alderweireld, Davinson Sanchez and Jan Vertonghen could make up his defence, with Kieran Trippier and Danny Rose being moved into midfield in wide positions.
Tottenham boss Mauricio Pochettinowill be forced to ring the changes for their match against Ajax (Image: GETTY/BUILDLINEUP)
Harry Kane has been ruled out with an ankle injury (Image: GETTY)
Son Heung-min is suspended after picking up his third booking of the tournament (Image: GETTY)
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They are expected to partner Moussa Sissoko and Eric Dier in midfield.
Pochettino will then be relying on Dele Alli and former Ajax star Christian Eriksen to supply Lucas Moura up front.
The game will mark Tottenham’s first Champions League semi-final after the north London side dispatched Manchester City over two-legs in a exhilarating quarter final.
Ajax have also impressed in Europe this season after already having knocked out Real Madrid and Juventus on their travels.
Spurs have only had three days rest after losing 1-0 to West Ham on Saturday, while Ajax have had a week off since they beat Vitesse 4-2 in the Eredivisie.