The 28-year-old arrived at White Hart Lane in 2014 for £8million and appeared 25 times in his first season at the club.
But Fazio has found himself frozen out of the set-up so far this season with one solitary game in the League Cup against Arsenal his only first-team outing of the year.
And on Monday he sealed a return to Sevilla, a club he first joined in 2007 and left seven years later for London.
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