United have never taken on the La Liga giants in a competitive fixture before, but played them in a friendly in 2013.
Sevilla have already come up against Premier League opposition this season though.
Eduardo Berizzo’s men finished second to United's rivals Liverpool in Champions League Group E.
They drew 3-3 with the Reds last month having been held 2-2 by them at Anfield in September.
United were among the top seeds for today's draw having topped Champions League Group A
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Jose Mourinho will lead Manchester United against Sevilla in the last-16 of the Champions League
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Manchester United finished top of Group A ahead of Basel, CSKA Moscow and Benfica
Jose Mourinho's side reached the knockout stages of this season's competition by finishing ahead of Basel, CSKA Moscow and Benfica.
United could have been pitted against Bayern Munich, Juventus, Sevilla, Shakhtar Donetsk, Porto or Real Madrid at today's draw in Nyon.
The Red Devils could not face Chelsea, runners-up in Champions League Group C, because teams from the same domestic league cannot face off until the quarter-final stages at the earliest this year.
The first leg will take place at the Ramon Sanchez Pizjuan on the 13/14 or 20/21 of February 2018.
The second leg will take place at Old Trafford on the 6/7 or 13/14 of March 2018.
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